Just read this on Politico:

Responding to speculation that Romney may be interested in the seat — which he challenged Kennedy for in 1994 — Eric Fehrnstrom, a spokesman for Romney’s political action committee, told POLITICO that the former one-term governor has no interest in campaigning to replace Kennedy.

“Gov. Romney’s focus right now is on helping other Republicans run for office, and that is how he will be spending his time,” he said.

Romney’s name had been floated in state political circles and among conservative bloggers as a viable GOP candidate, but Fehrnstrom said Romney absolutely will not run.

Probably a smart move, considering he’d have a hard time winning the seat since most people assume he’s going to make another run for the White House in 2012. If he were to lose, it would damage his campaign.

More than likely, Deval patrick is going to sign legislation allowing him to appoint the next Senator from Massachusetts. At least, that’s the direction he’s heading.